The human vomeronasal organ
The vomeronasal organ develops in utero. Nerve fibers emerge from the developing organ and travel towards the brain. This is a crucial step in the development of the reproductive system: as of puberty, gonad functioning depends on hormonal secretion by the anterior hypophysis, and this is governed by peptide GnRH secreting cells in the arcuate nucleus of the hypothalamus. Embryologically, these GnRH secreting cells derive from the olfactory placode, from which the olfactory and vomeronasal organs develop, and migrate along the vomeronasal axons toward the brain [23]. In humans, defective GnRH cell migration induces hypogonadotropic hypogonadism syndrome (LH and FSH pituitary hormone secretion defect), which is associated with absence or aplasia of the olfactory bulbs, orbitofrontal cortex alteration in the olfactory sulcus and reduction in or absence of olfactory sensitivity. After this initial development, however, the vomeronasal organ regresses, leaving only a few vestiges in adults [24,25]. Following Jacobson in the 19th century, Kölliker [26] and then Potiquet detailed the position of the vomeronasal cavities in adults: on base of the nasal partition above the foot, near the vomer bone. The cavity openings are now clearly visible on endoscopy (Fig. 2A) in some but not all individuals [25]. Histologic examination finds an internal canal of variable length, extending back and covered with ciliary epithelium with numerous underlying glands (Fig. 2 . Compared to in other mammals, the general structure shows many signs of regression: notably, absence of any veins or turgescent tissue able to produce active pumping. Immunohistochemistry confirms the absence of epithelial receptor neurons and even of underlying nerve fibers that might allow neural information to be transported to the brain [25]. With contrast medium injection, the cavities can be visualized on CT (Fig. 2C and D), at the base of the septum, above the foot of the partition. Read more: http://www.sciencedirect.com/science/article/pii/S187972961100010X